Radioimmunoassays, Ouabain-Like Material, and Ouabain
نویسندگان
چکیده
منابع مشابه
Radioimmunoassays, ouabain-like material, and ouabain.
Radioimmunoassays, Ouabain-Like Material, and Ouabain To the Editor: We read with interest the article by Bauer et al1 on the changes in the plasma concentration of a ouabain-like compound associated with vigorous exercise in both humans and dogs. The authors comment on the result that is most striking to us, namely the remarkably high concentrations of the immunoassayable substance achieved wi...
متن کاملEndogenous ouabain is not ouabain.
T he concept of a circulating digitalis-like inhibitor of the sodium pump, Na + , K +-ATPase, evolved from studies performed in the 1960s. De Wardener et al 1 addressed the question of whether a small increase in the glomerular filtration rate together with changes in the concentration of the more recently discovered hormone aldosterone could explain the natriuresis that generally followed salt...
متن کاملRadioiodinated tyrosyl-ouabain and measurement of a circulating ouabain-like compound.
BACKGROUND Assays for endogenous ouabain, a cardiac glycoside believed to be involved in blood pressure and volume regulation, are characterized by laboratory-specific plasma values that are measured by different assays. Because of this variability, our study focused on the development of a new (125)I-labeled ouabain derivative for RIA of high sensitivity. METHODS We generated rabbit antisera...
متن کاملOuabain-like activity in human cerebrospinal fluid.
Human cerebrospinal fluid has been found to mimic the effect of ouabain on net Na+ efflux and 86Rb+ influx across erythrocyte membranes and on the in vitro activity of a purified Na+/K+-ATPase (ATP phosphohydrolase, EC 3.6.1.3) derived from canine kidney. These results indicate the possible existence in human cerebrospinal fluid of an endogenous factor with ouabain-like activity, which might be...
متن کاملEndogenous Ouabain
In this brief article, we summarize recent reports about endogenous ouabain (EO), a cardiotonic steroid hormone. This includes analysis of mammalian EO, the discovery of EO isomers, regulation of intracellular signaling by EO, and the roles of EO in hypertension, pregnancy, and heart and kidney diseases. Novel ouabain-resistant mice that elucidate the key roles of α2 Na pumps and their cardioto...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2005
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.0000180069.86224.57